Topic: Oncology | Hospital Pharmacy Europe
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Tuesday 21 August 2018
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Topic: Oncology

July 26, 2018
Steve Wiliams explains why he loves working in the field of cancer care

Working with cancer patients can be tough at times as despite all the effective new treatments, many patients still have incurable diseases. But being an oncology pharmacist is an amazing job and I would not swap it for anything else. 
 

July 2, 2018
The CHMP has given a positive opinion recommending Novartis’s Kymriah (tisagenlecleucel) to treat two aggressive blood cancers.

The Committee for Medicinal Products for Human Use (CHMP) has given a positive opinion recommending Novartis’s Kymriah (tisagenlecleucel) to treat two aggressive blood cancers.
 
The CHMP, which is part of the European Medicines Agency (EMA), gave a positive opinion on using tisagenlecleucel to treat B-cell acute lymphoblastic leukaemia (ALL) that is refractory, in relapse post-stem cell transplant or in second or later relapse in patients up to 25 years of age.
 

June 28, 2018
First patient with metastatic breast cancer receives treatment to look at anti-tumour effect and tolerability using new drug response predictor

A drug trial on a patient with metastatic breast cancer selected by a new drug response predictor has been launched.
 

June 21, 2018
Targeted therapy to block a protein that suppresses T cell activity could improve cancer treatment with immune checkpoint inhibitors

A targeted therapy to block a protein that suppresses T cell activity could improve cancer treatment with immune checkpoint inhibitors, researchers have found.
 
EZH2 is elevated in immune T cells in patients after treatment with ipilimumab, a team at the University of Texas MD Anderson Cancer Center showed. The drug unleashes an immune response by blocking the activity of CTLA-4 on T cells – white blood cells that serve as the ‘targeted warriors’ of the adaptive immune system.
 

June 20, 2018
Manufacturer Amgen has received approval from the European Commission (EC) to include overall survival (OS) data on the labels of the drug BLINCYTO (blinatumomab), it has announced.

Manufacturer Amgen has received approval from the European Commission (EC) to include overall survival (OS) data on the labels of the drug BLINCYTO (blinatumomab), it has announced.
 
The EC granted the company a full marketing authorisation for the drug based on the overall survival date from the Phase 3 TOWER study in adult patients with Philadelphia chromosome-negative (PH-) relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).
 

June 14, 2018
International team of researchers have developed new DNA test to identify men at greatest risk of prostate cancer

A saliva based DNA test to identify men who are at the highest risk of developing prostate cancer is to start early trials.
 
An international team of researchers led by scientists at The Institute of Cancer Research (ICR), London, have developed the new DNA test to unearth new genetic variants that were particularly hard to find.
 

June 14, 2018
Cancer fighting effects of aspirin revealed in bowel tumour study

Taking aspirin could help to prevent bowel cancer, researchers have suggested.
 
Regular use of aspirin is known to reduce the risk of developing colon cancer but the drug’s tumour fighting properties have not been well understood. Researchers at theUniversity of Edinburgh have found that the painkiller blocks a key process linked to tumour formation, shedding light on how taking aspirin can help to stave off bowel cancer.
 

June 12, 2018
A first of its kind treatment vaccine has moved into a phase I clinical trial for patients with non-small cell lung cancer (NSCLC), under a collaboration agreement between Cancer Research UK and Asterias Biotherapeutics Inc.

A first of its kind treatment vaccine has moved into a phase I clinical trial for patients with non-small cell lung cancer (NSCLC), under a collaboration agreement between Cancer Research UK and Asterias Biotherapeutics Inc.

 

June 12, 2018
A first of its kind treatment vaccine has moved into a phase I clinical trial for patients with non-small cell lung cancer (NSCLC), under a collaboration agreement between Cancer Research UK and Asterias Biotherapeutics Inc.

A first of its kind treatment vaccine has moved into a phase I clinical trial for patients with non-small cell lung cancer (NSCLC), under a collaboration agreement between Cancer Research UK and Asterias Biotherapeutics Inc.

 

June 6, 2018
Evidence on whether cabozantinib increases the overall length of time people live is “less certain” says the National Institute for Health and Care Excellence

The National Institute for Health and Care Excellence (NICE) has issued draft guidance rejecting first-line use of Ipsen/Exelixis’ Cabometyx in renal cancer on the NHS.

 

Cabometyx (cabozantinib) is a treatment for adult patients with advanced renal cell carcinoma (RCC) following prior vascular endothelial growth factor (VEGF)-targeted therapy.

 

June 4, 2018
An antifungal medication, commonly prescribed for toenail infections, could help eliminate dormant cells within bowel tumours

An antifungal medication, commonly prescribed for toenail infections, could help eliminate dormant cells within bowel tumours, according to new research funded by Cancer Research UK and published in the Journal of Experimental Medicine on Thursday.
 
 

June 4, 2018
Inclusion in the Cancer Drugs Fund will give more women in England and Wales with recurrent, platinum-sensitive ovarian cancer access to ZEJULA via a managed access arrangement

TESARO, Inc. (NASDAQ:TSRO), an oncology-focused biopharmaceutical company, today announced the National Institute for Health and Care Excellence (NICE) will make ZEJULA®(niraparib), the first PARP inhibitor shown to be effective in patients with a BRCA mutation as well as those without a BRCA mutation, available to women in England and Wales with recurrent platinum-sensitive ovarian cancer via the Cancer Drugs Fund (CDF)[1]. 
 

June 1, 2018
Based on a recent planned review, the Data Monitoring Committee (DMC) recommends termination of Phase Ib/II study of daratumumab plus atezolizumab (anti PD-L1 antibody) in patients with previously treated non-small cell lung cancer

A mid-stage trial involving patients with pre-treated metastatic non-small cell lung cancer has been terminated after a combination of daratumumab (Janssen’s Darzalex) and atezolizumab (Roche’s Tecentriq) failed to show any benefit over the latter alone.
 
 

June 1, 2018
Nanoparticles carrying two drugs can cross the blood-brain barrier and shrink glioblastoma tumors

Researchers have devised a new drug delivering nanoparticle that could provide a better way to treat glioblastoma.

 

The particles, which carry two different drugs, are designed so that they can easily cross the blood-brain barrier and bind directly to tumour cells. One drug damages tumour cells’ DNA, while the other interferes with the systems cells normally use to repair such damage.

 

In a study of mice, the researchers showed that the particles could shrink tumours and prevent them from growing back.

 

May 18, 2018
Green light for advanced bladder cancer patients whose disease has progressed following chemotherapy

Patients with advanced bladder cancer whose disease has progressed during or after treatment with platinum-containing chemotherapy, can now access the new immunotherapy Tecentriq (atezolizumab) via routine NHS funding in England and Wales.1

 

May 11, 2018
Scottish Medicines Consortium gives positive decision for Stivarga® (regorafenib) for treatment of adults with hepatocellular carcinoma who have been previously treated with sorafenib

Stivarga® (regorafenib) has been accepted by the Scottish Medicines Consortium (SMC) as a monotherapy for the treatment of adult patients with hepatocellular carcinoma (HCC) who have been previously treated with Nexavar® (sorafenib).1

 

Regorafenib is the first medicine to be specifically licensed for second-line use in patients with HCC who had formerly been treated with sorafenib, the German multinational pharmaceutical company Bayer has announced.

 

May 10, 2018
Blood cancer drugs brentuximab, vedotin, midostaurin will now be available on the NHS giving hundreds of individuals more therapy choices

The National Institute for Health and Care Excellence (NICE) has recommended three blood cancer drugs, brentuximab vedotin, midostaurin and arsenic trioxide be made available on the NHS.

 

Two of the therapies, midostaurin, also known as the Novartis drug Rydapt, and arsenic trioxide, Teva’s Trisenox, are recommended for adults with certain types of leukaemia.

 

May 4, 2018
Herzuma is the third biosimilar to be marketed and distributed by the Mundipharma network in Europe

The Mundipharma global network of independent associated companies has announced that Herzuma, biosimilar trastuzumab, is now available in Europe, with the product now launched in both the UK and Germany and further launches across European countries anticipated in the coming months.
 

The Mundipharma network has exclusive distribution rights to Herzuma
in the UK, Germany, Italy, Ireland, Belgium, Luxembourg and the Netherlands.
 

May 3, 2018
Study finds the addition of this medicine to lenalidomide and dexamethasone (KRd) can extend the life of people with incurable blood cancer

The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended a label variation for KYPROLIS® (carfilzomib) to include the final overall survival data, following a recent Phase III trial.

 

KYPROLIS® is the first and only relapsed or refractory multiple myeloma treatment to demonstrate overall survival (OS) in two Phase III studies, Amgen, the American multi-national biopharmaceutical company, has announced [April 30].

 

May 3, 2018
Leading cancer charities launch awards to help advance understanding of the disease and develop new treatments to improve survival

Leading cancer charities have established a multi million pound fund to improve the understanding and treatment of brain tumours.

 

The Cancer Research UK Brain Tumour Awards was launched this month [1 May] by Cancer Research UK in partnership with The Brain Tumour Charity to help advance understanding about the biology of the disease and the challenges translating discoveries into treatments.

 

April 26, 2018
Personal cancer stories focus more on younger people despite majority of all cancers in the UK being diagnosed in over 60s

Older adults are underrepresented in the media’s coverage of cancer and cancer experiences, researchers have found. This is despite over three quarters of all cancers in the UK being diagnosed in those aged over 60.

 

According to research led by the University of Glasgow and funded by Cancer Research UK, articles featuring personal cancer stories more frequently focus on younger people.

 

April 19, 2018
Three studies shed light on cancer evolution and could lead to tests that give more accurate prognoses and personalised treatment

Kidney cancer follows distinct evolutionary paths, scientists have discovered. Their findings will enable them to detect whether a tumour will be aggressive, and also reveal that the first seeds of kidney cancer are sown as early as childhood.

 

April 12, 2018
Gene discovery could lead to future individualised therapy in myeloma, researchers find

Researchers have increased the understanding of the complex genetics behind an incurable blood cancer.

 

The Institute of Cancer Research, London, has conducted a study which has revealed 40 genes involved in the development of myeloma, enhancing the knowledge about the complex genetics associated with this condition.

 

April 11, 2018
After previous negative decision, NICE now recommends Tecentriq® (atezolizumab) for patients whose disease has progressed following standard chemotherapy

The National Institute for Health and Care Excellence (NICE) has recommended new immunotherapy for people with advanced lung cancer.

 

Biotech company Roche has announced that patients with advanced non-small-cell lung cancer (NSCLC) whose disease has progressed following standard chemotherapy, can now access its immunotherapy Tecentriq® (atezolizumab) through the NHS in England and Wales.1

 

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