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Tuesday 25 September 2018
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Topic: Infectious Disease

May 24, 2018
Juluca (dolutegravir/rilpivirine), has been endorsed as the first 2-drug regimen, once-daily, single-pill for the treatment of HIV

The first two-drug regimen to treat some patients with HIV in Europe has been approved ViiV Healthcare and Janssen have announced.

 

Juluca consists of ViiV’s dolutegravir, which is an integrase strand transfer inhibitor, and Janssen’s rilpivirine 25mg, a non-nucleoside reverse transcriptase inhibitor.

 

May 18, 2018
Nearly half of women with HIV lack help to manage menopause, a new study finds

Women with HIV are failing to get the support they need during menopause, according to a study led by University College London (UCL).

 

The PRIME (Positive Transitions through the Menopause) report  involved almost 900 women living with HIV aged 45-60 across England, who completed questionnaires and interviews between June 2015 and April 2018. Researchers found that 47% of women with HIV do not have the information they need to manage menopause.

 

May 3, 2018
<p>Immune cells are able to fight different strains of the same viruses, which could change the way vaccines are produced and given, a study finds</p>

Immune cells can fight different strains of the same virus, which could help transform vaccine development, researchers have discovered.

 

Vaccines become ineffective when a virus mutates, and tackling this problem is a priority for researchers. Vaccinations aim to stimulate the body to produce ‘memory’ cells which provide long-lasting protection from disease. It was thought that these cells could only remember – and be able to protect against – one particular strain of virus.

 

April 19, 2018
<p>Europe&rsquo;s national science and medical academies call for tailor-made interventions, European vaccination card and registry</p>

With the dramatic increase in measles in Europe – a four-fold increase from 2016 to 2017, according to a recent report by the World Health Organization – and the urgent need for vaccines protecting against infections for which no vaccines currently exist, the European Commission has drafted a roadmap for ‘Strengthened cooperation against vaccine preventable diseases’ and aims to adopt a proposal by mid-2018 for a Council Recommendation on Strengthened Cooperation against Vaccine Preventable Diseases.

 

March 13, 2018
The Steering Group on Influenza Vaccination was convened in November 2017, representing key stakeholders in the field of influenza. It is composed of eight members led by two co-chairs, including patient group representatives, healthcare professionals and academics

The Steering Group on Influenza Vaccination has released their Manifesto calling for more action to increase seasonal influenza vaccination coverage rates in Europe to reduce the unacknowledged burden of this disease.

 

March 1, 2018
Seqiris expects QIVc to be the first four-strain, cell-based seasonal influenza vaccine licensed in Europe, expanding the options available to help tackle the significant number of influenza-related deaths and hospitalisations in the region

Seqirus has announced plans to commercialise its novel cell-based quadrivalent influenza vaccine (QIVc) across Europe.

 

February 24, 2018
Researchers at the University of Glasgow have found a potential new weakness in the toxoplasmosis-causing parasite, potentially paving the way for new drug development for the disease

In a study published in PLOS Pathogens, scientists at the University of Glasgow’s Wellcome Centre for Molecular Parasitology have identified a key enzyme in the Toxoplasma parasite that is crucial for its survival, and may also be a potential new drug target.
 

February 22, 2018
Vosevi® is the first single tablet regimen for patients who have previously failed therapy with direct-acting antivirals

Gilead Sciences has welcomed the Technology Appraisal Guidance (TAG) issued by the National Institute for Health and Care Excellence (NICE), which recommends Vosevi® (sofosbuvir 400mg/velpatasvir 100mg/voxilaprevir 100mg; SOF/VEL/VOX).1

 

January 31, 2018
Letermovir is a first-in-class antiviral drug that inhibits cytomegalovirus replication

MSD has announced that the European Commission (EC) has granted marketing authorisation for letermovir as an orphan medicinal product for prophylaxis (prevention) of cytomegalovirus (CMV) reactivation and disease in adult CMV-seropositive recipients [R+] of an allogeneic haematopoietic stem cell transplant (HSCT).1

 

January 12, 2018
Bezlotoxumab is the first EC licensed non-antibiotic option indicated to prevent Clostridium difficile infection recurrence in high-risk adults

MSD has announced the UK launch of Zinplava® (bezlotoxumab) - a new therapy for the prevention of recurrence of Clostridium difficile infection (CDI) in adults at high risk for recurrence of CDI.1

 

Bezlotoxumab is administered as a single, one-off, one-hour intravenous infusion alongside standard-of-care (SoC) antibiotic therapy for the treatment of CDI.1

 

November 15, 2017
For patients undergoing an allogeneic haematopoietic stem cell transplant, complications arising from cytomegalovirus infection can be life threatening

The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion recommending approval of letermovir for prophylaxis of cytomegalovirus (CMV) reactivation and disease in adult CMV-seropositive recipients [R+] of an allogeneic haematopoietic stem cell transplant (HSCT).1

 

July 21, 2017
Proven efficacy and durability of darunavir combined with the improved renal laboratory and bone mineral density profile of emtricitabine/tenofovir alafenamide fumarate as compared with emtricitabine/tenofovir disoproxil fumarate in single tablet

Janssen-Cilag International NV has announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has issued a positive opinion recommending marketing authorisation for darunavir/cobicistat/emtricitabine/tenofovir alafenamide fumarate (D/C/F/TAF) (Symtuza), a new once-daily darunavir-based single tablet regimen (STR).

June 29, 2017
First and only option for acute bacterial skin and skin structure infections that offers a complete course of IV therapy delivered as a single 30-minute infusion

An intravenous antibiotic that could benefit patients and help reduce pressure on hospitals is now available in the UK.

 

Xydalba™ (dalbavancin hydrochloride) is an IV antibiotic approved by the European Medicines Agency (EMA) for the treatment of acute bacterial skin and skin structure infections (ABSSSI) in adults. It is the first and only option for ABSSSI that offers a complete course of IV therapy delivered as a single 30-minute infusion.

 

May 5, 2017
CDI, a potentially fatal disease, is three times as deadly as MRSA and is estimated to cost the EU €3 billion per annum

Data presented  at the 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2017, demonstrate benefits of extended-pulsed fidaxomicin (EPFX), compared to standard vancomycin.1
 

March 8, 2016
Universities of Dundee (Scotland), & Cape Town (South Africa) partnering with Bayer (Germany)

World-leading medicinal chemistry and biology at the Universities of Dundee (Scotland) and Cape Town (South Africa) have been allied to the industrial expertise of the Pharmaceuticals Division of Bayer (Germany), one of the world’s leading pharma companies, in an effort to develop critically needed new treatments for tuberculosis (TB).
 

November 19, 2015
Investigational HCV regimen with ABT-493 and ABT-530 evaluating a pan-genotypic, once-daily treatment option with shorter duration of therapy
August 19, 2015
Antibiotic Research UK will announce at its Annual General meeting its first research programme to tackle antibiotic resistant bacteria (superbugs)
August 10, 2015
This article covers antiretroviral therapy, aims of treatment and when to start therapy, resistance, management of toxicities, adherence, and current and future treatment strategies

 

August 7, 2015
In a busy London tertiary hospital I start my day by replying to any urgent emails relating to antimicrobials

In a busy London tertiary hospital I start my day by replying to any urgent emails relating to antimicrobials.  At the moment I am coordinating the quarterly antimicrobial prescribing audits with the pharmacy department ensuring that the data is collected within the two week period, before analysing the data to produce a report on how different medical areas are complying with set measured criteria.

 

July 9, 2015
Zevtera® (Ceftobiprole medocaril): the latest generation Cephalosporin with broad-spectrum of activity launches in the UK
June 24, 2015
Tuberculosis sufferers will be able get drug treatment sooner thanks to a new whole genome sequencing technique

Tuberculosis sufferers will be able get drug treatment sooner thanks to a new whole genome sequencing technique to determine for the first time which drugs to give sufferers, researchers in Oxford have reported.

 

University of Oxford researchers at the John Radcliffe Hospital have developed a genetic test – details of which are published online in the Lancet Infectious Diseases – that can detect which drugs will effectively treat people with the disease and those that will not.

 

June 10, 2015
More than 200,000 people in the UK are chronically infected with hepatitis C, (1) of which only an estimated 3% are treated each year, despite the advent of treatments that can offer viral elimination. (1)

More than 200,000 people in the UK are chronically infected with hepatitis C, (1) of which only an estimated 3% are treated each year, despite the advent of treatments that can offer viral elimination. (1)

May 19, 2015
Data presented from the CDI Service Evaluation study shows that the adoption pattern of treatment impacts CDI outcomes. Compared to traditional broad-spectrum antibiotics, first-line use of fidaxomicin, a targeted treatment, in all CDI patients provides improved outcomes in terms of recurrence rate, all-cause mortality and cost effectiveness, compared to use in selected patients only. (8) CDI is associated with high-mortality (5,6,7) and cost burden, (9) therefore reducing the incidence and recurrence of CDI is a priority for clinicians, payers and health authorities alike.
May 11, 2015
This could help health service providers to better treat disease, control transmission of this infection, and monitor outbreaks. Tuberculosis (TB) disease rates in some parts of London are as high as in Sub-Saharan Africa, and drug-resistant strains are becoming increasingly common. These require specific treatments, and if doctors know that a bug is resistant they can start therapy earlier, often leading to better outcomes.

This could help health service providers to better treat disease, control transmission of this infection, and monitor outbreaks. Tuberculosis (TB) disease rates in some parts of London are as high as in Sub-Saharan Africa, and drug-resistant strains are becoming increasingly common. These require specific treatments, and if doctors know that a bug is resistant they can start therapy earlier, often leading to better outcomes.

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