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Sunday 26 May 2019
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Topic: Featured Articles

May 17, 2019
A new study describes a method of reprogramming regulatory T cells that usually suppress immune responses into inflammatory cells that not only permit but also intensify an antitumour immune response
A new study from the Center for Immunology and Inflammatory Diseases (CIID) at Massachusetts General Hospital (MGH) describes a method of reprogramming the regulatory T cells that usually suppress immune responses into inflammatory cells that not only permit but also intensify an antitumour immune response.1 
 
April 16, 2019
Standardisation of doses of intravenous chemotherapy agents was initially proposed to improve pharmacy capacity and reduce medication errors and wastage; however, further optimisation of the administration of anticancer drugs can potentially contribute to a more efficient oncology unit

Key points
 
• Dose standardisation can reduce the risk of calculation errors, decrease preparation time, and reduce waste.
 
• Pharmacists play a critical role in the preparation of chemotherapy and the verification of prescriptions.
 
• An analysis of prescriptions by BOPA identified 2.3% errors that could result in patient harm.
 

April 12, 2019
This opinion piece considers the different technologies used for the preparation of cytotoxic injections and infusions: pharmaceutical isolators, Class II cytotoxic cabinets and closed system transfer devices (CSTDs)
Cytotoxic chemotherapy is synonymous with a narrow therapeutic index, severe adverse effects for patients and occupational exposure risks for pharmacy and nursing staff.
 
March 26, 2019
Could dose de-escalation be an alternative strategy to decrease drug exposure, related risk, and treatment‐related costs while maintaining clinical remission in IBD?
The introduction of anti-tumour necrosis factor (anti-TNF) therapy in 1999 revolutionised the management of inflammatory bowel disease (IBD). The TAXIT trial introduced widely therapeutic drug monitoring (TDM) to tailor anti-TNF therapy and optimise the limited treatments options more effectively, particularly supporting decisions around non-response, loss of response and dose intensification.1 
 
March 26, 2019
The SLE populations of the pivotal BLISS-52 and BLISS-76 trials constitute large patient cohorts, ideal for post-hoc survey to better understand the disease itself, and the effects of belimumab treatment
The treatment of systemic lupus erythematosus (SLE) has traditionally been non-specific, comprising glucocorticoids, non-steroidal anti-inflammatory drugs and broad immunosuppressive agents. 
 
The monoclonal antibody belimumab towards the soluble counterpart of the B cell activating factor belonging to the tumour necrosis factor family (BAFF), also known as B lymphocyte stimulator (BLyS), is the only targeted therapy approved by regulatory agencies for SLE, and has been available for use since 2011.1
January 15, 2019
Former regional pharmaceutical officer for the Israeli Ministry of Health Yaakov Cass outlines his views on how hospital pharmacists should handle hazardous drugs

Former regional pharmaceutical officer for the Israeli Ministry of Health Yaakov Cass outlines his views on how hospital pharmacists should handle hazardous drugs
 
Can you tell our readers a bit about yourself?
 

December 10, 2018
A scientific approach is essential in distinguishing between fully contained systems and filter-based alternatives and hospitals and compounding centres are encouraged to do their own research on the efficacy of all systems on the market before making a decision
As hospitals and compounding centres look to upgrade their safe handling standards in compliance with regulation, there are many factors to consider.
 
September 28, 2018
Hannah Beba is a senior pharmacist practising in the diabetes and endocrinology fields at the County Durham and Darlington NHS Foundation Trust. She is also one of the charity Diabetes UK clinical champions and an independent prescriber. She talks to Léa Legraien about her successes, challenges and love for the profession.

Hannah Beba is a senior pharmacist practising in the diabetes and endocrinology fields at the County Durham and Darlington NHS Foundation Trust. She is also one of the charity Diabetes UK clinical champions and an independent prescriber.
 
She talks to Léa Legraien about her successes, challenges and love for the profession.
 
 
Q Why did you become a pharmacist?
 
 

August 23, 2018
Working as a pharmacist in the Central African Republic and the Democratic Republic of the Congo was a rewarding experience, despite considerable challenges, explains Barbara Pawulska

Working as a pharmacist in the Central African Republic and the Democratic Republic of the Congo was a rewarding experience, despite considerable challenges, explains Barbara Pawulska
 
What with busy dispensaries and tricky patients to contend with, life as a pharmacist can present challenges in any walk of the profession.
 

August 1, 2018
More than 3000 participants from 75 countries gathered in Gothenburg for the 23rd congress of EAHP. The meeting covered a range of hospital pharmacy activities and highlights included biosimilars in oncology, advanced therapy medicinal products and post-operative analgesia
Anna de Goede
Anna de Goede
 
Richard Langford
Richard Langford
 
Eric Viel
Eric Viel
July 31, 2018
Delivering a clinical pharmacy service within an NHS acute trust has many challenges, not least of which is the conflict between workload demands and staffing resource.

Abstract

Aims

The clinical pharmacy services leads at Manchester University NHS Foundation Trust (Wythenshawe site) have designed and implemented a service delivery model utilising a pharmacy digital tracker board and workforce management system that allocates staff based on patient risk and workload. The aim of this paper is to describe the flexible service model and examine outcome measures pre- and post-implementation.

 

Methods and results

July 31, 2018
Spinal anaesthesia using hyperbaric prilocaine allows faster recovery and can significantly increase efficiency and throughput in day surgery, delegates heard at the B Braun satellite symposium held during the European Association of Hospital Pharmacists Congress in Gothenburg in March
Support for the development of this report was provided by B Braun
 
July 31, 2018
Biologic patent expiry offers the potential for huge cost savings through the use of biosimilars, although newer biologics appear more clinically effective. Is it possible therefore to resolve the issue of cost versus efficacy?
July 23, 2018
The introduction of dose banding and the recent publication of product specifications by NHS England have set the ball in motion for the introduction of licensed standardised chemotherapy doses, the benefits of which are discussed here
Chemotherapy is the single biggest service area-spend within NHS England specialised commissioning. In 2016/17, NHS England spent approximately £1.7 billion on the routine commissioning of chemotherapy, with drug costs accounting for the largest proportion (80%).1
 
July 18, 2018
The UK’s National Health Service turned 70 this month, and while we celebrate the achievements of one of the nation’s most valuable institutions, it’s also the perfect opportunity to pinpoint the role that pharmacy has played in the NHS during those decades.

The role of pharmacists in the NHS has, unsurprisingly, evolved quite a bit since its inception. Growing from what was originally a supply service to become a clinical practice in hospitals, and with a range of new roles in primary care, pharmacists are now recognised as a valuable part of the multidisciplinary clinical team.
 

July 11, 2018
The European anti-counterfeiting measures will come into force in February. Léa Legraien gives pharmacists all the information they need to make sure they’re ready

The European anti-counterfeiting measures will come into force in February. Lea Legraien gives pharmacists all the information they need to make sure they’re ready 
 
The Falsified Medicines Directive (FMD) will come into force on 9 February 2019 in the UK, as mandated by the European Commission (EC), to tackle counterfeit medicines and improve patient safety.
 

February 9, 2018
Setting new standards of care through automated ward medication dispensing cabinet refills is now a reality at STS AG Hospital in Switzerland

Support for the development of this report was provided by BD

 
February 9, 2018
This article focuses on the most commonly observed toxicities observed in patients treated with chimeric antigen receptor (CAR) T-cell therapy
February 9, 2018
Individualised parenteral nutrition (IPN) has an important role in the management of more nutritionally complex and fluid restricted preterm infants. This article provides an overview of, and current perspectives on, preterm IPN
February 9, 2018
More than 500 people attended the German Hospital Pharmacists Association (ADKA) congress in Würzburg in 2017. Topics included computerised prescribing, advanced therapy medicinal products and landmark clinical papers
“Don’t allow a situation to develop in which doctors think you have a bad [electronic prescribing] system – negative associations tend to persist”, Steffen Härterich (Pharmacy Department, University Hospital of Hamburg-Eppendorf) advised. Dr Härterich has been responsible for the introduction of electronic prescribing in a hospital that already made use of electronic systems for stock control and patient records and wished to implement systems to deal with prescribing, decision support and medication safety.
 
February 9, 2018
A variety of measures can improve the safety of medicines including using standardised injectable magnesium sulphate, flushing of intravenous lines and implementing global coding, symposium participants heard
Alan Wilkinson
Alan Wilkinson
 
Clare Howard
Clare Howard
 
February 9, 2018
The calm waters of parenteral nutrition (PN) compounding are being stirred up by the long anticipated arrival of KabiHelp, Fresenius Kabi’s new PN compounder

Support for the development of this editorial was provided by the Business Unit Compounding of Fresenius Kabi

 
At Fresenius Kabi, we are focused on being a full service partner by providing a complete parenteral nutrition (PN) solution to patients through the hands of health care professionals. Moreover, with our KabiHelp Compounder, tailor-made, individualised admixtures, for preterm to geriatric patients, can be produced, while reducing the need for manual additions.
 
February 9, 2018
Hospital pharmacists manage the consequences of drugs shortages, balancing budgets, managing supplies and minimising the risk of clinical errors associated with unfamiliar packs or products but many factors are beyond their control
December 15, 2017
Thrombotic thrombocytopenic purpura (TTP) is an acute, rare, thrombotic microangiopathy and current therapies and newer treatments expected for future care are discussed

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