This site is intended for health professionals only
Thursday 20 June 2019
Share |

Vectibix® and best supportive care improves overall survival in mCRC

Amgen announced the presentation of detailed results of a Phase III study with Vectibix® (panitumumab) and best supportive care (BSC) compared to BSC alone.  The study met its primary endpoint, demonstrating a statistically significant improvement in overall survival (OS) in patients with chemorefractory wild type KRAS (exon 2) metastatic colorectal cancer (mCRC; n=377 total). This is the first Phase III Vectibix study to include an analysis of efficacy of Vectibix by wild-type KRAS (exon 2) and in wild-type RAS tumour mutation status in its primary analysis, providing important information about OS in these populations. These results, in addition to secondary endpoint data, were presented at the 2016 Gastrointestinal Cancers Symposium (GICS) in San Francisco.


The study (GICS abstract #642) showed that patients with wild-type KRAS (exon 2) mCRC treated with Vectibix and BSC achieved a median OS of 10 months compared to 7.4 months for patients treated with BSC alone (hazard ratio [HR]=0.73, 95% confidence interval [CI]=0.57-0.93, p=0.0096). Data from a key secondary endpoint showed that patients with wild-type RAS (absence of mutations in exons 2, 3 and 4 of KRAS and NRAS) mCRC treated with Vectibix and BSC achieved a median OS of 10 months compared to 6.9 months for patients treated with BSC alone (n=270; HR=0.70, 95% CI=0.53-0.93, p=0.0135).


Patients with mutant RAS mCRC did not benefit from Vectibix treatment (n=54; OS HR=0.99, 95% CI=0.49-2.00). The safety profile was comparable to the known safety profile of Vectibix when administered as a single agent, with skin, nail, gastrointestinal and electrolyte disorders being the most frequently reported adverse events.


Amgen has played a significant role in the advancement of personalised medicine, applying cutting-edge science and technology in our efforts to target therapies to the patients who are most likely to benefit. Amgen is committed to understanding cancer biology through studies like this,” said Sean E Harper, MD, executive vice president of Research and Development at Amgen. “As well as providing additional insights into the way Vectibix works in mCRC, these data support expanding biomarker screening to include wild-type RAS.


Colorectal cancer is the third most common cancer worldwide, with approximately 1.2 million cases occurring globally each year.1,2 Approximately 20% of colon cancers are diagnosed at the metastatic stage, when the disease has already spread to distant organs, a diagnosis associated with only a 12% five-year survival rate.3 Using molecular approaches to identify unique genetic signatures in mCRC has the potential to help improve treatment outcomes. Of the few biomarkers in colorectal cancer, RAS genes (KRAS, NRAS) have a validated impact on treatment outcomes.4,5


Abstracts are currently available on the GICS website.  



  1. Ferlay J et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. Accessed 9 June 2015.
  2. Jemal. Global Cancer Statistics. CA Cancer J Clin 2011;61:69–90.
  3. Colon Cancer Alliance. Get Information: What is Colon Cancer: Statistics. Accessed Dec. 3, 2015. Available at:
  4. Fight Colorectal Cancer. Biomarker Testing for Colorectal Cancer: Common Biomarker Tests for Colon Cancer. Accessed Dec. 3, 2015. Available at:
  5. Colon Cancer Alliance. Get Information: Treatment: Biomarkers. Know Your Biomarker. Accessed 3 December 2015. Available at:

Ads by Google

You are leaving

You are currently leaving the Nursing in Practice site. Are you sure you want to proceed?


Respect for nurses: Sign up to our e-petition TODAY

The Nursing in Practice Respect campaign is now live! Over the coming months, we're set to highlight the vital contribution and efforts of primary care and community care nurses throughout the UK.

As part of our campaign, Nursing in Practice is looking to call on parliament to set up a debate to celebrate the vital work that you do.



Calling all primary care nurses! 'Like' our Nursing in Practice Facebook page to enter our free draw to win a £25 M&S voucher