This site is intended for health professionals only
Wednesday 12 December 2018
Share |

Researchers make breakthrough on sexually transmitted bacterium

Scientists have discovered the mechanism by which a bacterium adheres to human cells, which is essential for the onset of bacterial infection and disease development.
 
The researchers from the Molecular Biology Institute of Barcelona (IBMB) and the Institute of Biotechnology and Biomedicine (IBB) studied the bacterium mycoplasma genitalium (Mgen) and how it adheres to human cells.
 
They found the mechanism by which it interacts with cells, which the researchers hope will lead to new treatments to fight the infection.
 
IBMI researcher and first author of the study, David Aparicio, said: “We made a protein crystal of the P110 adhesin bound to aialic acids and used X-rays to determine the exact position of the atoms within the protein, and we were able to decipher the three-dimensional structure.”
 
Mgen infections are as frequent as gonorrhoea infections, according to the study, which is one of the most common sexually transmitted diseases.
 
The bacterium is sexually transmitted and causes urethritis and cervicitis, pelvic inflammatory disease, premature birth and spontaneous abortions. It is also becoming resistant to antibiotics.
 
IBB researcher Oscar Quijada said: “On the one hand, we have obtained key information on the process of colonization – that is, how the pathogen comes into contact with the host cells. On the other hand, it allows us to develop alternative drugs capable of blocking Mgen’s cell adhesion, such as molecules mimicking the human cell receptors, or stimulating the formulations of antibodies which can inhibit the function of these adhesins.”
 
Researchers said finding alternative ways of treating Mgen were of the “utmost importance” given its resistance to antibiotics.
 
The study, published in the journal Nature Communications, has led to an international patent application and a new study that aims to fight the emergence of new resistances.


Ads by Google

You are leaving www.nursinginpractice.com

You are currently leaving the Nursing in Practice site. Are you sure you want to proceed?

Close

Respect for nurses: Sign up to our e-petition TODAY

The Nursing in Practice Respect campaign is now live! Over the coming months, we're set to highlight the vital contribution and efforts of primary care and community care nurses throughout the UK.

As part of our campaign, Nursing in Practice is looking to call on parliament to set up a debate to celebrate the vital work that you do.


GET INVOLVED: SIGN OUR E-PETITION

Close

Calling all primary care nurses! 'Like' our Nursing in Practice Facebook page to enter our free draw to win a £25 M&S voucher




http://www.facebook.com/NursinginPracticeMagazine