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Wednesday 20 March 2019
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New drug could reduce risk of allergic reaction to peanuts in children and adolescents

AR101 slowly builds up tolerance to peanut allergy, study finds

A new oral biologic drug could reduce the risk of allergic reaction in children and adolescents following accidental peanut exposures, research has shown.
 
AR101 slowly builds up tolerance to peanut allergy, a study published in The New England Journal of Medicine found.
 
Researchers conducted PALISADE, a Phase 3 randomized, double-blind, placebo-controlled trial of oral immunotherapy (OIT) with AR101 in peanut-allergic patients aged 4 to 55 in Europe, the United States, and Canada.
 
Eligible subjects reacted at a challenge dose of 100mg or less of peanut protein (approximately one third of a peanut kernel) during a double-blind, placebo-controlled food challenge (DBPCFC) at screening.
 
The study looked at the proportion of participants aged four to 17 years of age who could ingest a challenge dose of 600 mg or more, without dose-limiting symptoms.
 
Study participants completed initial escalation and up-dosing phases, approximately six months of 300 mg per day maintenance treatment, and then an exit DBPCFC.
 
None of nearly 500 four to 17-year-olds taking part in the study could tolerate even a tenth of a peanut dose.
 
But after a year of taking small daily doses, 67% were able to ingest a dose of 600 mg or more of peanut protein, without dose-limiting symptoms, at the exit food challenge, researchers found. 
 
However, no significant effect was found in participants 18 to 55 years of age.


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